Database : HANSEN
Search on : ESTUDOS SOROEPIDEMIOLOGICOS [Subject descriptor]
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Id:17277
Author:Mohammad, Hatta
Title:Epidemiology of leprosy: molecular, biological, and immunological approach ..-
Source:s.l; s.n; 2003. 10 p. tab.
Abstract:Leprosy is an infectious disease for which humans are considered the only source of infection. The major hindrance in leprosy control and thus in reaching the elimination goal is that numerous leprosy cases remain undetected for a long time. Many of these patients are a continuous source of infection and, and hence perpetuate transmission. The goal of the World Health Organization (WHO) is to eliminate leprosy as a public problem by the year 2000; that is, to reach as a global prevalence of <1 per 10,000 people. The epidemiological data generated routinely by health services are greatly influenced by their policies and activities. The data do not, however necessarily reflect the true situation in the field. Information on the magnitude of the leprosy problem in any one area is important for the health services with regard to their planning, monitoring and evaluation of leprosy control activities. Our studies have suggested that the high prevalence of antibodies in children may be indicative of the active transmission of M. leprae in their surroundings. The prevalence of these antibodies may also be important for leprosy control programs in order to detect new patients as early as possible and in an effective and sustainable manner. Based on PCR data, it seems that the environment also plays an important role in the transmission of leprosy in endemic areas. The results of our study show that contact with a leprosy patient is the major determinant in the incidence of leprosy and that this concept shows similarities with the "stone-in-the-pond" principle of tuberculosis transmission in concentric circle around patients. (AU).
Descriptors:Anticorpos
Análise por Conglomerados
DNA Bacteriano
Predisposição Genética para Doença/*GE
Geografia
Incidência
Hanseníase/BL/*EP/TM
Mycobacterium leprae/GE/*PY
Prevalência
Estudos Soroepidemiológicos
Limits:Humano
Location:BR191.1; 09176/s


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Id:12316
Author:Geraminejad, Pedram; Memar, Omeed; Aronson, Iris; Rady, Peter L; Hengge, Ulrich; Tyring, Stephen K
Title:Kaposi's sarcoma and other manifestations of human herpesvirus 8 ..-
Source:s.l; s.n; Nov. 2002. 15 p. ilus, tab.
Abstract:Kaposi's sarcoma (KS) was described by Moritz Kaposi in 1872 and was known for an entire century as a rare disorder of older men usually of Eastern European, Mediterranean, and/or Jewish origin. In the early 1980s, the prevalence of KS began to increase dramatically and soon became the most common malignancy in patients with AIDS, especially those who were male homosexuals. In 1994, a new human herpesvirus (HHV) was found to be present in almost 100% of KS lesions. This virus was found to be a gammaherpesvirus, closely related to Epstein-Barr virus, and was designated HHV-8. Subsequently, HHV-8 DNA was found in almost all specimens of classic KS, endemic KS, and iatrogenic KS, as well as epidemic KS (ie, AIDS KS). It is now believed that HHV-8 is necessary, but not sufficient, to cause KS and that other factors such as immunosuppression play a major role. The use of highly active antiretroviral therapy (HAART) since 1996 has markedly reduced the prevalence of AIDS KS in western countries, but because 99% of the 40 million patients with AIDS in the world cannot afford HAART, KS is still a very common problem. Primary effusion lymphoma and multicentric Castleman's disease are also thought to be due to HHV-8. Although HHV-8 DNA has been described in a number of other cutaneous disorders, there is little evidence that HHV-8 is of etiologic significance in these diseases. The mechanism by which HHV-8 causes KS, primary effusion lymphoma, and multicentric Castleman's disease is not well understood but is thought to involve a number of molecular events, the study of which should further our understanding of viral oncology. (J Am Acad Dermatol 2002;47:641-55.) Learning objective: At the completion of this learning activity, participants should be familiar with Kaposi's sarcoma and other manifestations of human herpesvirus 8..
Descriptors:PRODUTOS DO GENE TAT
INFECÇOES POR HERPESVIRIDAE
HIPERPLASIA DO LINFONODO GIGANTE
INTERLEUCINA-6
LINFOMA DE CÉLULA-B
LINFOMA DE CÉLULA-B
SARCOMA DE KAPOSI
SARCOMA DE KAPOSI
SARCOMA DE KAPOSI
SARCOMA DE KAPOSI
TERAPIA ANTI-RETROVIRAL DE ALTA ATIVIDADE
FASES DE LEITURA ABERTA/fisiologia
HERPESVIRUS 8 HUMANO/fisiologia
ESTUDOS SOROEPIDEMIOLOGICOS
Limits:HUMANO
Location:BR191.1; 0274/cme


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Id:11332
Author:Nijhawan, S; Vijayvergiya, R; Agrawal, S; Jain, S; Rai, P. R
Title:Seroprevalence of hepatitis C virus in various groups living in captivity ..-
Source:s.l; s.n; 1997. 2 p. .
Descriptors:HEPATITE C
ANTICORPOS PRESENTES EM HEPATITE C
INDIA
HANSENIASE LEPROMATOSA
RETARDO MENTAL
PREVALENCIA
PRISIONEIROS
ESTUDOS SOROEPIDEMIOLOGICOS
Location:BR191.1; 07271/s


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Id:9747
Author:Klatser, Paul R
Title:Serology of leprosy ..-
Source:s.l; s.n; 1994. 4 p. .
Descriptors:LEPROSTATICOS
HANSENIASE
HANSENIASE
HANSENIASE
HANSENIASE
HANSENIASE
PROGNOSTICO
ESTUDOS SOROEPIDEMIOLOGICOS
TESTES SOROLOGICOS/MT
Location:BR191.1; 06702/s


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Id:9205
Author:Lima, Edimo Garcia de; Borras, Maria Rosa Losano; Araujo, Maria Aparecida
Title:Estudo da precipitacao entre os soros de portadores de hanseniase ?-
Source:s.l; s.n; 1982. 8 p. tab.
Descriptors:HANSENIASE
PRECIPITAÇAO
IMUNODIFUSAO
ALBUMINAS
IMUNOGLOBULINAS
RADIOIMUNOENSAIO
MYCOBACTERIUM LEPRAE
ANTICORPOS
ANTIGENOS
HANSENIASE LEPROMATOSA
HANSENIASE TUBERCULOIDE
ESTUDOS SOROEPIDEMIOLOGICOS
Location:BR191.1; 06169/s



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